Bay area would be killin two birds with one stone, my lady's aunt lives out there (we've been out twice to visit), only bummer is the cost. Flying for 3 gets costly nowadays, which is why I mentioned the train ride. We did it the first visit, was a ton of fun, despite a long delay home. We're also in the O.C. area a lot for the Angel games, that coinciding with a con would be great.
Downtown would be even less costly (for us, at least) too, metrolink is close by.