I flew for quite a bit this morning and no problems after I changed the power settings to never. I heard Skuzzy say something about that once.
Do you have a powered USB hub? If you don't you WILL have trouble. While CH isn't as power hungry as some Saitek stuff they still pull alot of juice. If you don't have a powered hub your computer power supply must supply power for ALL your USB units as well as the MB, video card, and sound card, and fans.
I have a full CH setup as well. Mine is on a powered USB hub and has been for years and I never have had any trouble.