Game patches do not change settings, unless we explicitly list it as one of the things changed. Even then we do everything we can to preserve those settings.
Other things can have an impact, which we have no control over (USB resets, anti-xxx software interfering, Windows 10 update resetting calibration...).
I challenge anyone to find a patch which actually accessed the "settings" folder, where we said nothing about it. The files that are touched, in a patch, are listed as the patch is installed.