Talon, I recal my evo in game everytime I log in.
Mostly because of habit from my bad experience with logitech crap. (my previous stick was a wingman)
I have noticed though, that if I don't it will occasinally lose calibration. However, by calibrating it each time I log in it has given me pretty good service for a year now.
So , I guess the answer to your question is yes.
Cheers,
RTR