many people are very different about how they map the profile
a few things i did when i had an x45:
the thumb button on the throttle was programmed as "look up" so while holding that and the hat i got 16 total views.
i did not use the pinkie switch far alt mode or whatever, i set it to toggle WEP
make sure to make the rotaries analog, then you can map them in AH as axis for elevator and aileron trim (or rudder, whatever you prefer)
on the index finger hat on the throttle, i set it for:
DOWN = mic channel
UP = mic range
LEFT = clipboard
RIGHT = auto level (kind of odd place for it, but it worked for me)
on the thumb hat on the throttle i set it for a 4 way hat, front and back did flaps (or shifting gears in a GV, same keys)
there are sooooo many options, i think it is best to play around, and see what keys you personalyl use the most, and find where they are comfortable.
last, if you are using rudder pedals, you have a free axis in the rocker. i banded it, and made it "move head right and left"