I use indirect water heaters and a boiler in all the installations I do. You never run out. Im up north though so Im sure it wouldnt be efficient for warmer areas. The tankless we have are the type emmersed in the boiler and bolted to the face of it. Depending on the water conditions, minerals can form inside the coil, coating the walls and insulating the water to be heated, from the boiler water. You may think "I'll just turn up the temp of the boiler".
This will work for a short time, but it actually excelerates the process, and you will eventually end up without hot water. Flow restricters do help slow the water down a bit, so it has time to heat before flying thru the coil, to the faucet.