The game resources are quite a bit larger than they use to be and video cards have gotten faster. Simply put, if you preload into the video card memory, you will run the card out of RAM. Now, you can pretty much ignore the amount of video RAM being used, as shown in the game, as we have found out it does not reflect reality.
Back on track, when you run a video card out of RAM, it has to swap to/from system RAM. NVidia's later drivers have an issue when this has to be done a lot. Aside from that issue, there is no real reason to preload into video RAM. One of the manifestations of the problem is no texture being applied to a poly in the scene. NVidia seems to be happy to draw a blank poly when another frame is ready to be drawn.
The problems get exacerbated when using anti-aliasing, which is a popular option to use on high end video cards, due to the amount of video RAM used for this task. More swapping.
You will not get any performance gains from preloading into video RAM and can induce problems by using it.