MU-2 / Cirrus is an apt comparison.
Good airplanes with a lot of pilot-error crashes.
With the Mu-2, I think it's because of some tricky procedures that really require someone to be on the ball. With the Cirrus, I think it's because they're aggresively marketing a high performance plane to low time pilots.
BTW, the Columbia is fantastic. If I had a choice between the two, I'd be in the Columbia in a heartbeat. Niiiice planes, and a much better safety record per sold airplane.