I had a Sony Viao desktop a couple of years ago and once you removed all the fancy plastic covers it seemed like a standard case and could probably accept an aftermarket MB. You should check out the wattage on the power supply though, it may not be big enough. My sony came with a 350 watt power supply (the power supply died) It came with 1 60GB HD, 1gig ram and a DVD player, I added a bigger video card, an 80GB HD, another gig of ram, and a RW Cdrom. i think thats what killed the power supply. I just started over with a new case and 500 watt power supply and new MB/processor and swapped everything else to the new case.