The game cannot find its resource files to load. This can be due to a lot of things. Primarily it has to do with the exectuable not being run from its installation folder (i.e. it got moved to the desktop when trying to manually create a shortcut to it).
You can remove the game (Add/Remove Programs in Control Panel) and reinstall it without losing your settings, if you install back into the same folder you removed the game from.
