I travel weekly and rent weekly. I've used every car rental company that is out there, the only company I have rented from for the last 5 years is Enterprise. Best rates, most locations, can arrange drop off and pick up. They also allowed me to open a coproate account with them to take advantage of an addition 15% discount with no limitations ever. I'm self-employed so I eat the expenses. Big difference when I only have to pay $80.00 for a 4 day rental as opposed to $150.00.
The insurance is a rip off, Your own Automobile insurance will most likely cover you completely also some credit cards have an automatic insurance coverage plan, you need to check, but after 25 years of traveling and renting weekly, I've never needed it. Google your maps have them with you and a small flash light , I don't get the GPS it's to distracting, I figure I am already driving on unfamiliar roads don’t need additional distractions. But map quest or google maps does a pretty good job and can get airport to address turn by turn directions . I always get them in both directions also, from the airport to the hotel and from the hotel to the airport.