Underwater you can easily enter all the spectrum of the atmospheric diffrence, however not the limits, since underwater there is always pressure. There is no number close to zero pressure. Does that make a difference?
Not sure about eardrums, but it will eventually with life and death and then you have the tales of "bends" and how differently they worked on people.
So, your body can cope with 1 feet underwater, or 33, or even 333.
But it will not cope with 50K for long. At 50K you start to need pressure for breathing. So I guess what I am saying is that maybe the pressure difference alone is not the main element, the human body exposed to extreme low-pressure needs to be taken into account as well.