Yes...I ran into problems...
My SB card would not work at all..Audigey 2ZS with W7x64...and neither would the RealTek Mobo sound drivers...
It wasn't until I unloaded the SB card, unloaded the drivers, unloaded the RealTek drivers and let the native Win7x64 OS do its own searching did the mic finally work...and that was after some fiddling with the sound/record controls as well...
You are not alone...there are dozens if not hundreds of google search pages regarding issues with W7x64 and 32bit sound hardware...
Oneway