I like the ASRock boards. I built a system awhile back with the Dual-VSTA board which was nice because it accommodated old DDR ram and new (at the time) DDR2 ram. Also supported both AGP and PCI-e video cards.
Worked great as a stopgap to upgrade to a C2D cheap. Later I upgraded to DDR2 ram (2GB) and then went from a NV5200 AGP to a NV6200 AGP to a 7900GT PCI-e card. Got a couple of years out of it, then I gave it to my brother as a gift when I got the upgrade bug yet again. He still plays WOW several hours a day on it with no issues!
I now use the ASRock G43Twins-FullHD board (got it on sale cheap). It came with a 'displayport' PCI card for the video (which I'm sure shares resources with the onboard video), but I never even installed that in the first place, using a NV9800GTX and shortly after an ATI5830 card instead. It also supports DDR2 or DDR3 ram... and even claims to use solid capacitors.
I even overclock a little with no issues and never experience any crashes. I'm sure it's probably not the best performer out there, but the reliability and compatibility seems to be worth it.
As for what your wife needs, you can literally pick out the cheapest case, motherboard, processor, and ram (that is all compatible) from newegg and it would likely be more than what she needs, but whatever you do, don't skimp on the power supply.