I don't think that the Me 410 would be particularly good at shooting down B29s.
Because a 388 mph (30 mph faster than the B29) level top speed and a 50mm cannon (if we get that variant) wouldn't do? Even with 6 20's or 4 20's and 2 30's, the 410 may be the ONLY ride that could intercept successfully a B29 in this game.
It would be the only heavy fighter to have the ability to engage for an extended amount of time....(considering mossies generally don't fair well in this role, due to the wooden construction)
Sorry, but your statement has no logic contained.