The Lancaster was originally the twin engined Manchester and its wing was enlarged from the Manchester's when it was converted to be the four engined Lancaster.
Old topic, but I've been reading SAM Publications' fascinatingly detailed book on the Lancaster, which has a short chapter on the Manchester. Quoting from page seven, "the design was also to be capable of dive bombing (at an angle of 60 deg to conceal the type and also to offer better accuracy of ordnance delivery), torpedo dropping (this led to the very long bomb bay as the torpedoes of the time were 18ft 3in long), troop carrying and supply dropping!". The fashion at the time in both Britain and France was for multi-role aircraft, the idea being that this would save money by consolidating the same roles into fewer aircraft types. The French went for smaller designs, such as the Potez 540 and the Bloch MB 130 and so forth, we had the Manchester and the Blenheim. I surmise that the requirement for a long bomb bay would have forced the designers to make the fuselage extra-specially rigid, in the same way that convertible cars need scuttle reinforcement. This in turn would have increased the weight, which is one of the factors that doomed the Manchester.
Quoting further, "the long range of heavy bomb load of the type was to be achieved by the use of a catapult take-off". What appears to have happened is that all of these requirements were included in the original design, but dropped as requirements just before production finally started (the dive bombing requirement persisted until August 1938), so presumably they were engineered in but never used. The book describes a catapult launch of one of the Manchester prototypes. The MkIII Manchester had lengthened wings, presumably built to the same standard as the Manchester's original set, although ultimately the MkIII became the Lancaster.
All of this probably explains why the Lancaster was such a piece of work. Interesting to compare it with the Ju 88, which had a similar range of roles but was much smaller; I wonder if the Germans ever thought of putting four engines onto the thing? Probably would have made no sense unless the bomb bay was enlarged, at which point it's becoming a completely new aeroplane, and if you're going to build a new aeroplane, why not start from scratch and make the best! With the war as good as won there's no rush.