As much as possible I try to set MP and RPM as I would/did in real life....part of the fun for me.
On the B-29 I've noticed that at altitude when you reduce RPM the manifold pressure doesn't change. I haven't operated a 3350 but I do have several hours with Wright 1820s and PW 1830s. The MP should decline as the RPM is reduced. The supercharger/turbocharger is a big airpump, if you slow the pump down there is less air pumped, MP will drop.
Also the low RPM stop seems to be too high. On the Ham Standards on the B-17 and B-24 you can bring the RPM back to 1200. In fact on the runup when you excercise the props you look to be sure the RPM does drop to 1200 to be sure the prop/governor is working correctly. On the AH B-29 I was only able to reduce to 2000 RPM until MP was reduced substantionaly, then only able to bring RPM down to 1600 until throttle was reduced enough that the RPM was responding to throttle.
Minor points, have no big effect on the game but in the interest of realism/immersion would be nice to see this corrected.
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