I am always hesitant to answer questions like that. I have seen super-monster systems that could not play Tetris without stutters. I have seen low end systems that could run with every piece of eye candy cranked up.
It all depends on the software installed and the configuration of said software.
Windows and many applications (Intuit, Roxio, Apple, McAfee, Norton are just a few of the bad guys) are just nasty that way.
From a purely hardware perspective, it will not be able to run very well with a shadow texture size larger than 1024, if you enable everything else. Then again, it will depend on how many bad guys are in view. I am also assuming Windows 7 64 bit will be used as the operating system.
Quite frankly, if the game is set to its maximum where 256 planes (representing every plane in the game) can be in view and all have their own skins, there is not a video card on the planet with enough video RAM to handle it.