When your wife starts muttering things like "When we end up in divorce court over this, don't act surprised." To me this is a good indication it's time to step away from the keyboard for a while, put duskcovers on the HOTAS, etc.
FYI - I find flowers and a dinner date help get things back on track quickly i.e. miss only a week of a tour or one FSO frame. Your mileage may very, however.