Guitars are like joysticks 
You need a tool kit to get them right 
Which is not a bad thing 
Guy at work pick up acoustic from a second hand shop a old epiphone, looked like poo 
Flippen thing was awesome 
A lot of younger (playing time, not age) players don't realize the value of having a properly set up and intonated instrument. Makes all the difference in the world. Pretty much any thing right off the wall is going to need to be restrung, have the neck, action, and intonation set at the very least. Depending on build quality it could also need fret work, new nut, wiring etc. to get it really ready to go.
Another trap people fall into is buying based only on the brand name. More guitars than you would think are products of ghost building. A good deal of "Brand name" guitars are built overseas and just quickly QC'd once they hit stateside.
Find something with a neck that feels comfortable to your hand. Most of the rest of it can be fixed/tweaked by a good luthier, or at least someone who knows how to do a proper set up.
Guitars in my current lineup...
80s ESP Horizon Custom
80s ESP M1 Custom
91 ESP M1 Graffiti
90s American Strat (for studio work)
90s Ovation 1869 Custom Legend
90s Ovation Celebrity
90s Peavey Foundation S
Probably adding a 12 string acoustic and 5 string bass in 2014.