Hi Changeup,
If you have the supporting hardware (CPU, mem, monitor, etc) that will not bottle neck it then the answer is yes & do it easily. But this goes for most of the offerings out there today. Due to some personal choices I make I don't usually use this card w/ totally maxed graphics settings (only reflections aren't fully maxed as I can't visually tell any difference in-game...all other in-game graphics settings are fully maxed out) but I have tested & ran this card in AH running flat out & steady at max FPS of my monitor (59 FPS) & at fully maxed out graphics settings regardless of what is going on in-game.
I will also say this again as I have done a LOT of testing w/ this GTX Titan along w/ a GTX 670 FTW vid card on my box running AHII:
Nvidia's GPU Boost--whether it is vers 1 or 2--will not fully boost a Nvidia Kepler GPU on my box to max boost clocks using the in-game AH graphics settings (AA slider) due to the in-game SETTING level only, regardless of slider position. The game runs excellent but not w/ the Kepler GPU running at max boost clocks....most of the time they ran BELOW the BASE boost clock speeds even w/ all in-game graphics settings at max & GPU temps/power ranges WELL below the throttling thresholds. This can cause the game to fluctuate on FPS when running on a Nvidia Kepler GPU.
When I turn off the in-game AA setting (slider set to None) & set the AF, AA, Trans AA & TF settings to max settings at the Nvidia driver level (after setting the driver to override any application settings...the graphics settings that are set within the game itself do not affect GPU Boost...only the AA slider does) & then GPU Boost would run the GPU while playing the game at the max boost clock settings allowed in BIOS as long as the GPU temps/power ranges were below the throttling thresholds & game runs hiccup-free w/ all other in-game settings maxed out full. This is w/o any OC'ing on the GPU or CPU on my box. The only time I have noted this Titan to clock back (and subsequent FPS drop) was due to the GPU power range hitting the 100% power threshold on occasion as set in the BIOS (have verified this using Precision X)...GPU temps have never exceeded 67*C under full load conditions. This is due to the game loading when at a large field that is under attack w/ a LOT of stuff burning & a LOT of friendlies/cons present. Making 1-2 bumps off full reflections updates or upping the GPU power threshold to 110% usually fixes this issue. I will usually just back off the reflections setting for my tastes as I visually can't see any difference in the reflections when set less than full. The only thing that I haven't tried yet is disabling Intel SpeedStep to my I7 3820 lock the CPU speeds to it's max speed settings to see if this has any effect to the game running (CPU will throttle it's speeds due to load/power levels....just like the Kepler GPU does). The potential CPU throttling may fix this as well but I haven't tested this yet so I can't say.
Note on GPU Boost: If I lower the Nvidia driver AF set below 16x or the AA set below 16QxCSAA or the TAA set below 8xSS or the TF set below High Quality GPU Boost will not boost GPU to max boost clocks but will boost to a % below max boost due to the SETTING used, regardless of the GPU temps/power ranges being below the throttling thresholds then may go to max boost clocks due to in-game graphical loading.
In short, if you want to ensure full GPU boost clocks are being used w/ a Nvidia Kepler card using GPU Boost in AHII I recommend using the Nvidia driver settings mentioned above set to max settings then tailor the rest using the in-game graphics settings to your liking.
I can easily OC this Titan and/or CPU & NEVER hit any graphics wall playing AHII in it's current configuration but due to it very seldom reaching this limitation in stock trim I can accept leaving it in stock trim. Now when HTC releases their updated software w/ the updated graphics engine all this may change....................
I can't say 60 FPS as I set my monitor to use 59 Hz to avoid the rounding issues & so my FPS stays at 59 FPS running at 2560x1440x32 res. This way I don't need any of the gadget software solutions.
Is it worth the $1,000.00 to get this kind of performance.....the answer is no. Since this card came out there are other models available in both camps that can do this for a lot less money. Heck my GTX 670 FTW could do it on my box but I wanted a Titan so I got 1...........& I don't regret buying it to this day.