Cheers, when last I flew if the interceptors weren't at altitude before I broke into the open I could at least get to the strats, getting home could be a different matter, but the 16's a joy when light. (All assuming a flak ping in the port wing didn't PW me...)
The Moss16 defense other than speed is maneuverability. The problem is that if you took the two drones you cannot maneuver without losing them and their perks. A single Moss16 is much more survivable, can frustrate an attacker repeatedly and make the fight a very drawn out event - enough for friendly escorts to intervene. However, by not taking the drones the player lose 66% of its poundage in bombs. In addition, B17s 30K speed with the ridiculous buff gunnery is more survivable - not per plane, but you get three free "strikes" before you are completely down, as opposed to the mossie in which you effectively get just "one life" with or without the drones.
I use a single Moss16 as a town buster with the MOAB in the bay. Last time I dropped one on a town I got 23 system messages of destroyed structures and field guns. Got bounced by a P-51 which I dodged twice till friendly fighters were all over him and made my way home in a shallow dive holding 400 mph most of the way. Landed 6000+ lbs of damage from a single 4000 lbs bomb

The nice thing about this mission profile is that it is very efficient - climb out on WEP to get to 8Kft is barely 3 minutes and not much more is required. Arrive at 300 mph and the release point is quite a few miles before the target, so after release I make a nose-low 180 turn and race for home, never actually reaching your target. Unless I want to drop the 500 lbs on something else, then I just fly away for one minute and make a quick turn back for another run if not chased by fighters. Sometimes fighters are not too quick to engage me, especially if I visited the field before in the air-superiority Mossie VI - they cannot tell if I an a fighter again or the bomber version until very close range.
I really wish I had the useless 303s in the bomber. I'll be able to find use for them then.