Hop #5, where the packet loss starts, is in your ISP's network. You need to get this to them and see if they are having issues.
Forget the first line of support at your ISP, they will only check you local connection. You need support beyond that first line.
The packet loss on the next to last hope is happening on the return trip in your ISP's network as well.
Ping Plotter and other such utilities can only show the path to the destination. Any errors on the return trip are always show at the last or next to the last hop.