The USAAF and RAF both modified a Spitfire Mk IX to increase its fuel load to allow to Berlin and back escorting, but then the P-51B happened and long range Spitfires weren't needed.
This is a theoretical exercise. I'm proposing a small bit of alternative history.
The basic premise is something along the lines of some bright spark in the Air Ministry recognising in very early 1941 that the PR Type G - an armed Mk IA with a 29 gal rear fuselage tank - meant that a long-range Spitfire was a realistic proposition, and then shouting down the opposition from Portal and Douglas in April/May/June 1941 and actually developing the bloody thing.
This leads the RAF to develop the Spitfire as a long range fighter. The alternative proposal I've got in mind is roughly this:
LR Type 1: 85 gal front tanks + 29 gal rear tanks for 114 gal - in service by June/July 1941 - radius of ~220-230 miles
LR Type 2: 96 gal front tanks + 29 gal rear tanks for 125 gal - in service by September/October 1941 - radius of ~230-250 miles
LR Type 3: 96 gal front tanks + 29 gal rear tanks + 20 gal in wing tanks, for 145 gal - in service by April/May 1942 - radius of ~ 280-300 miles
LR Type 4: 96 gal front tanks + 29 gal rear tanks + 26 gal in wing tanks, for 151 gal in service by June/July 1942 - radius of ~ 290-310 miles
Add various drop tanks - 30, 45, 90 gal slipper tanks, or torpedo/blimb style 44/45/50/54 gal drop tanks - to add more range as these become available.