I'm wondering if they'll ever construct and fly a newer shuttle in the future. The tech now is significantly better than when they constructed the original shuttles, as such, safety is also likely to be much better. Though price of a getting a shuttle into orbit and back is still as high (if not higher) as it was for the original shuttles, compared to the pods they use right now (capsules are much smaller, therefore lighter and cheaper to get into orbit). Can't even imagine the science and logistics required for shuttles, though definitely much higher than that of a pod.
I remember as a kid, imagining a Shuttle orbiting the Moon on some kind of mission. I will continue to hope for a day like that despite the fact that it doesn't look like it will happen anytime soon.