Open the Clipboard> Graphic Details. There's a bunch of check box to disable things. Try them one at a time, starting from the obvious looking ones. There's also settings that aren't "natural" like Lens Bloom. Those are actually meant for making AH films as they add the camera effect. So they usually can and should be disabled until you're making a video.
As you didn't tell what your new card is or other details of your system it's impossible to tell whether the culprit is the game or your system. A DxDiag output as an attached .txt file would help if the above doesn't.
