Back in the day Skuzzy said that AH graphics are designed to use the default settings of any video card - in Nvidia control panel that means "application controlled" for most settings which in turns means that all settings are done in within the game. At least that method doesn't interfere with other graphics in your computer.
That said, Animl has good tips on his site.
Lastly, familiarize yourself with the settings of your monitor! For home office use a neutral preset is good, but for gaming you may want a more vivid colour scheme.