Guys, please let me know what OS version you are running, if you have a VIA chipset board, what version of the 4-in-1's you have, and most importantly what version of the Detonators you are using. Often "later" models of the Detonators will be less stable than some of the earlier models.
Also, if you are overclocking anything at all, the first thing you should try is turning it all back to stock speed. AH puts more load on certain parts and areas in the CPU (notably the FPU) than other games or apps. Turn the OC down to stock and try AH. If that works, you can start slowly ramping the OC back up until you find the stable spot. If it works at stock speed, you know the problem is with the OC stability and you can work from there.