Ever ridden before? Totally new to bikes? Or just getting back into them?
If you have never ridden, my advice is buy an el cheapo dirt bike and learn to ride it. Once you master a motorcycle onthe off road, then you are almost ready to deal with a street bike with your new skills. Recall its not the motorcyclist getting themselves killed most often, its the other damn drivers!
If you have ridden and are looking for something comfy, you have something in common with Abunabi. He's a big guy (wont dare guess weight) and about 6'2. New is graciously overpriced this time of year. But for a bigger guy, forget the bend-you-in-half bikes like the GSX-Rs and such. Some of the older Ninjas, like ZX-10s and ZX-11s are mighty comfy...a tad heavy, but comfy. Ideally, sit on a few, see whats best for you.
Among my favorites are FZR-1000s from the early to mid 90s. Very powerful, yet suprisingly comfy. I've had a few Ninja 600s (pre ZX-6 era) that were very fun to ride all day too.
I've never owned a Honda, but some of the CBR's seemed comfortable to me, but Im 5'9 & 170 pounds. I always wanted a Honda CBR, but everyone seemed to have one....Ive always liked having something a little different.
So, that's my advice...Kawasaki ZX-10/ZX-11 and the bigger FZRs. You didnt say a price range, but with the economy a bit down now, you should find plenty used.