That shouldn't be a problem at all. maybe I'm lucky, but I've not even had a problem with the MB swap. A short while ago I had the retail fan on my Athlon XP freeze solid resulting in a bios beep code situation on boot.
I was in the middle of an edit cycle, on deadline with 3 90% completed articles due the next day, so I hooked the HD up to a secondary lan gaming machine and a few automatic plug and play moments later and I was up and running with good stability. It helped that both systems used different via chipsets (but the same 4-1 driver pack) and different video cards (but the same Nvidia driver pack) and the same sound card (SB Live) Lo and behold, after an involved troubleshooting process that led to finally to porked memory (with an new MB and new processor which had to be blown too, I hope), I hooked the HD back up to the new system (again a via MB), and it plug and played its way back into a stable system after the second boot. All with Win 98 SE. YMMV of course, I was amazed.
Charon