Most of the tweaking you can do in the bios relates to ram timings and the like. To tweak with them you really need to have both quality ram and a good understanding on how Dram operates. (Either that, or find some information on what timings others with your brand and speed of ram are able to achieve.) If you push the ram too hard, you'll end up with an unstable system, or worse yet, corrupt data files.
Typical ram options are (without getting technical on what they mean):
CAS (column address strobe) latency. (2, 2.5, or 3 are common settings) (This is the mysterious "CAS" rating you see marked on ram.
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Active to Precharge (Usually 4 to 6 cycles)
Command Rate (1 to 3 cycles common)
On the above, the lower is better.
Bank Interleave. (None, 2 way, 4 way.) Not all motherboards support this, but this improves memory performance significantly if enabled.
