Until Lindbergh convinced the guys in the 5th AF to do otherwise, the P-38 was flown at low (about 16-18") MAP/autorich/2600RPM. This not only caused excessive fuel consumption, but also fouled plugs. Another problem it created was that it dropped cylinder head and oil temperatures well below proper operating levels. This caused the engines to run rough and hesitate when the throttles were advanced upon entering combat. It also caused the turbos to overspeed because the oil was congealed in the turbo regulators. This was yet another area where the USAAC and Lockheed dropped the ball.
The incident that caused Lindbergh to attempt to convince the 5th AF to use his fuel method was an prettythang chewing he got from a flight leader for taking too long to clear the runway as planes running out of fuel were waiting to land.
Lindbergh told the guys in the squad he was flying with to try flying at 36"MAP/autolean/1600RPM. The mechanics went nuts, swearing the Allisons would be junk in one flight. However, Mac MacDonald, the CO, set about testing the idea out. After a few flights, they found fuel consumption was dramatically reduced, and that the engines actually ran smoother and responded much better to the throttles. The mechanics removed the engines from the plane and found they were in excellent shape, better than the engines in any other plane.
Unfortunately, this information was never adopted by the 8th AF. It would have made a big difference in many ways. They'd have had a lot more fuel to fight with (in most deep penetration escort mission profiles there was less than 5 minutes of WEP allowed if you wanted to have fuel to get home), and the problems of fouled plugs, burnt valves, dropped valves, dropped valve seats, chucked rods, ruptured intercoolers, and shattered turbos would have been nearly non existent.
The biggest drawback to using the Lindbergh settings was that it required you to do more switching and adjusting when entering combat. You had to switch to autorich,and increase your RPM, BEFORE slamming the throttles open. Add that to having to turn on both the gunsight and the gun heaters, and having to reset the radiator and oil cooler doors, not to mention switch the fuel selectors and drop the tanks if running on external, and you get real busy real fast. If the flight leader made the call to go combat ready before you engaged, that was okay, but if you got bounced, it was touch and go.
The fuel capacity increase in the J-5-Lo and later P-38s was 110 USG. Changing the intercoolers to the core type and placing them in the fuselages instead of using the leading edges of the wings as complex intercoolers allowed the engines to make more power, and the space freed up made room for a 55 USG tank in the leading edge of each outer wing.