Glary utilities, free download from download.com, easy enough for anyone with opposable thumbs to use.
Yet has individual tools for power users who know what they are doing.
What I like most, we'll use their startup manager as an example.
Click on the startup manager in GU, box pops up with everything that is currently set to start when windows starts in a list. Unsure what one of those entrys is? Highlight it, right click "google it".
Web browswer pops up, you get the "official" answer as to exactly what the program is, if it should be enabled, should be disabled, or can be left to your choice. Plus you get other peoples opinions.
So as you go through each entry, its "teaching" you whats starting when windows starts. And which ones might be best to leave be, which ones can be safely turned off.
Does the same thing for process manager!
And it does a really good job of cleaning out the garbage in its 1 step scan and fix problems.
Which checks and fixes registry, shortcuts, as well as checking for malware, etc.
You want a really good set of tools for free that you can teach your grampa to run, get Glary Utilities.