You used to be able to run some. Now just small programs, sharewares or indy software will let you do that. Nowadays any modern software has many registry entries (and Adobe? Good GOD they have tons!) that won't let the software run without checking first. If it can't find them, it can't run.
That's why I will copy the files over to get any working files, and projects, but I always have to reinstall the software packages themselves.