Sure, disable all the unneeded devices in the BIOS. First disable them in the Windows device manager, then reboot to the BIOS and disable them. After rebooting, check the device manager and see if they are still there and disabled.
You should be able to move the PCI/USB board to another slot and with a dedicated IRQ. Normally, slot 1 is shared with AGP, slot 2 and 5 are shared, slot 3 is usually shared with some onboard device, and slot 4 could be by itself.
Check the motherboard manual and see if they list what slots are physically sharing IRQ's with other devices.
You may have to manually set the IRQ's in the BIOS roms, once you have freed the COM/LPT device IRQ's.