If the power draw from the USB ports comes close to the limits of the built-in hubs, then a brown-out condition can occur where the USB hub sends millions of interrupts to the CPU causing a heavy spike in CPU usage.
In Windows 7, it was a critical condition which could cause the system to crash. In Windows 8, and later, Microsoft instituted a hack/fix, of sorts, which shuts down the USB hubs ability to generate an interrupt and then they switch to polling mode. It is less efficient and uses more CPU time, but it keeps the system from crashing.
To my knowledge, there has never been a motherboard which had full support for the power draw limits specified for the USB bus.
Oh Bizman, my early response about the older chip sets was more of an FYI thing that may or may not have anything to do with the system in question.