Interesting..............
Well I'll fall on the other side as I've used a Belkin ExpressPort 4-port USB 1.1 hub in bus power mode (drew power from the mobo USB cluster) w\ my CH HOTAS for 15+ yrs w\o issue until the Belkin finally gave up the ghost but to be fair the only items plugged into the hub were the CH controllers & this setup was the only USB items plugged into the mobo USB cluster I designated for their use to maintain the necessary power regulation to the hub thus controllers.....just as AckAck has stated.
I ran this config thru 6 different mobos & 3 different power supplies w\o issue so it is possible & does work well but it will depend somewhat on the controllers being used along w\ the quality of the USB hub & it's A-B cable as far as power regulation\usage & signal quality is concerned. I will also agree that using a powered USB hub does give a much wider margin of stability as long as it's power supply isn't overloaded.
Either way it all comes down to quality\capability of power regulation to either make or break the setup. I would imagine that the advent of VR ramps the power usage requirements up a few...........
I now currently run my CH HOTAS off the usually unused 2 internal mobo USB 2.0 headers thru a USB 2.0 4-port slot adapter out the back of my box using 3-3' USB 2.0 extension cables to get the connection points for my CH HOTAS outside of my desk slot so that I can disconnect my controllers w\o having to pull my box out if desired so in effect I'm still using them off the mobo USB 2.0 headers (MSI MPG X570 Gaming Plus) along w\ a Seasonic PRIME Gold 850W PSU feeding it all & they've been rock steady ever since for the last 5-6 yrs.
Hope this helps.