i am suprised how many fly "with or without" no exceptions it seems.
i use combat when doing most manuevers, and general flying, manual trim when in tight places, or where it gives me an edge.
i have "toggle combat trim" mapped to a button, and the rotaries of the x45 throttle mapped to the trim bands. when in combat trim they do nothing, but as soon as i turn off combat trim, they work.