I'm a lefty and therefore cannot use the x45,52 or whatever the other top of the range sticks are with a seperate throttle controll for two handed play. BUT..... in damaging my Cyborg Evo, I purchased a new one, so I now have two Cyborg Evo's.
Instead of chucking the old one, I programmed the throttle, spare buttons and the hat to my old stick thus giving me two handed play, as a lefty I can use the throttle and spare hats and buttons on my right hand, while using the traditional controlls with my left. Neat!