I dont know what the setting actually DOES, but it did cause problems for me once.
Having it on cause me to have freezes every time i started a transmission. Unchecking it solved the problem back then. While i was busy finding the issue and trouble shooting, i heard others had similar difficulties but the other way around, ie they had to have their box checked.
My (PC clueless) guess would be that its a hardware/driver specific thing that you either need or you dont.