John Varley's Steel Beach book is interesting. Humanity exists on Luna and the rest of the planets/moons in the solar system, exclusing the Jupiter system. The reason? Aliens, who they refer to as "The Invaders", came in and, without any fuss or muss, exterminated humanity and its works on Earth, almost casually, then went to Jupiter. Humanity speculates that it has something to do with the whales, and evidence suggests that The Invaders have established a colony inside of Jupiter, but at no point is there any contact. It is as if humanity is insect-like in significance to them, and that they are so far advanced as to be beyond comprehension to the humans.
There's very little chance that actual alien contact will be like Star Trek, where the major races are at about the same technology. Look at what humanity did in 65 years, from first airplane to first moon landing. Now think about how the universe is billions of years old. If one culture just develops 1% faster than another... they're at "magic" level while the next guy is still learning that the trick is to bang the rocks together.