Since you didn't post any real information. Don't run dual video cards in SLI mode (it's wasted on this game and barely supported by the drivers)...if you're using Windows Vista make sure the game is installed outside of C:\Program Files...if you're running Windows Vista, try Win98 compatibility mode...
When you're done whining, post your dxdiag info and any other pertinent information you have about your system and maybe one of the HTC people will have some suggestions for you.