I'm not so much saddened by the shuttles retirement, though I do think they are really cool. They have far exceed their designed service life, and are ridiculously expensive to operate, they should have really been retired 10 years ago.
What saddens me is the cancellation of the Constellation program (supposed to replace the shuttle), it would have been much cheaper, much safer, and lift more then the shuttle. Also the last administrations program to return to the moon. It hits home to me, I know many people who have been laid off from ATK Thiokol (built the shuttle's SRBs), not to mention some folks at ATK spent years working on designs for the Constellation program, only to have the President say "Sorry, we changed our minds." I know the political line is that the private sector will step up and take over, but realistically the private sector is 30 years behind NASA. Branson and Scaled Composites, have just barely got the private SpaceShip one into suborbital space. Besides NASA, while being tax payer funded, has created hundreds of thousands of private sector jobs, NASA pulls it all together , but most of the components, and much of the research IS done by private firms.
I have lots to say on this topic, but most of it would get *see rule #14*