Mosquito Mk XVI was not a low altitude Mossie. Its best speed is had at 28,000ft, at which altitude the only F4U that can catch it is a -4.
If you think intercepting the Mossie XVI in anything other than a rocket is easy, well, you've never had to intercept a Mossie driver who knew what he was doing.
Let me put it this way, if a Mossie XVI crosses a sea level airfield at 28,000ft at the same time that a Bf109K-4 takes off to intercept it the Bf109K-4 will be so far behind by the time it reaches 28,000ft that it would need to run WEP for 45 minutes in order to reach firing range. Good luck.
Further, if it were unperked, it would just end up being used to sling 4,000lb bombs at GVs.
When did the Mossie start getting perked?
The late war bomber version, not the fighter version, Meatwad.