For me, effective bomber hunting starts with watching the dar bars and which fields they came from.
If I see dar bars coming from high altitude fields deep in enemy territory, I watch thier progress to see if my country is the target and then send a 110g to 34k AFK climbing to where I am guessing the buffs will show up.
Then I come back and see what's around me within the radius of my range.
If done right, you can intercept most any plane with most any plane if you have enough altitude advantage.
A mossie at 39,000 feet has an amazing loiter time for higher or faster targets/ but it suffers pilot wounds easily as if had zero armor.
A 262 is fast enough once you get up there that you can catch up to someone's buffs and catch them unaware.