Power fluctuations with Windows 7 or Windows 10 can cause crazy things with USB controllers.
USB 'brownouts' are not uncommon with the Saitek stick. When it happens, the stick will eventually get a new USB ID, which will make it appear as a new stick to the game.
All versions of Windows, from Vista and up, have this issue. The simplest way to prevent it from happening is to use an externally powered USB hub. The X52 draws a lot of power through the USB port. Right up to the maximum allowed. If the internal USB hub of the computer has anything else attached to it, then brownouts can happen, quite easily.