What anti-xxxx software is it? Most of them cannot actually be disabled. All disabling does is turn off the reporting of problems.
You cannot rely on Windows 10 to keep drivers updated, especially video card drivers. Microsoft is usually several releases behind. NVidia had a couple of drivers, recently released, which had a number of issues. They have been releasing hot fixes pretty regularly, which never get to Microsoft.
I am thinking there is something else going on here. Random lockups, not occurring with everyone playing the game, usually point to something else. What are the temps of the video card and CPU? What size/brand/model power supply is in the computer?