I realize it's not worthy of a sticky, but I"m copy/pasting/savubg Skuzzy's post related to resolution and game/target sizes for future use, this comes up an awful lot still.
Ever since Drex famously reduced his res to 800x600 from the typical 1024 res many ran back then (myself included, although sometimes a bit higher), when he beat all comers, there has been much discussion, disagreements, etc, regarding what reducing the resolution does to the size of the targets on the same screen/monitor.