Are you using a powered USB hub? If not I would suggest you do.
Windows tends to power down usb and the X52 uses plenty of power with all those lights and display.
Smarter guys than me can maybe help with the USB power setting but as I said I would get a powered USB hub and you shouldnt have the issue anymore. I used an X52 for years and never had to calibrate it after the first time,using a powered hub.