I'd rather suggest that the AN-225 project was motivated more by politics than by demand. If the USA can build a 747, the Russians are driven to build something larger.
Had the airplane made sense from an operational standpoint - runway performance - range- it's very ability to fit into commonly used airports, then its likely more might have been built.
Its Russia's airplane and they can do what they want but rebuilding it makes as much sense to me as rebuilding a De Havilland Comet.